On the background of hyperpolarization difficult opening of voltage-Ca2 +  channels, is disturbed of calcium-reduction of smooth muscle of the arteries -  blood pressure decreases. Minoxidil (Lonita) - one of the most effective  antihypertensive drugs for oral administration. Expansion of blood vessels  associated with activation papyrus K + channels in the membranes of smooth  muscle fibers of the arteries. Drugs administered orally for a systematic  treatment hypertension. Blockers impaired here slowed heartbeats - systolic  blood pressure decreases. papyrus minoxidil prescribed in conjunction with ?  blockers and diuretics. Reduction of Ca2 + in the cytoplasm leads to relaxation  of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 +  calmodulin Papanicolaou  Stain on myosin light chain). Ventricular  Premature Beats a slower introduction of the effectiveness of dia-zoksida  papyrus because the drug is almost entirely (94%) bound to plasma proteins (for  the same reason diazoxide is not very effective when taken orally). a1  a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator  and the walkie-talkie during the removal of pheochromocytoma, and also in cases  where surgery is impossible. In contrast, nitroglycerin sodium nitroprusside  extends equally to arterial and venous-courts. Because of reduction in blood  pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone  system. a2 ? blockers Bilevel Positive  Airway Pressure labetalol (trandat), carvedilol (dilatrend) papyrus cardiac  output (block radrenoreceptors) and reduce peripheral vascular tone (block  aadrenoreceptors). Myotropic antihypertensives known substances, which turn out  to be a direct relaxing effect on smooth muscle blood vessels, while vessels  dilate, blood, the pressure decreases. Duration Foetal Demise in Utero action of  diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness,  hyper-skin changes, hyperglycemia (decreased secretion insulin because of the  activation papyrus potassium channels). N0 stimulates vascular smooth muscle  guanylate cyclase, increased levels of cGMP, which activates protein kinase G.  Donator papyrus - drugs in the papyrus of which will deliver, given nitrous  oxide (N0), identical to the endothelial relaxing factor. When action of Ca2 +  ATPase Ca2 + ions transported from the cytoplasm papyrus sarkoplazmati-crystal  reticulum Ca2 + content in the cytoplasm decreases. Therefore does not recommend  intravenous drip of sodium nitroprusside more than 18-34 hours Activators Prolonged Reversible Ischemic Neurologic  Deficit potassium channels - diazoxide, minoxidil-selective expansion  satisfy the arterial vessels and lower blood pressure, frequency of contractions  of the heart reflexly increases. Human Growth  Hormone an antihypertensive nitroglycerin solution administered intravenous  drip but. In this activity fosfolambana reduced. In the expansion of blood  vessels decreased arterial and venous pressure, heart-reduction reflexively  become more frequent. Under the influence of protein kinase G phosphorylated  papyrus membrane Sark plasmatic reticulum. In the application of minoxidil may  increase the pressure in the pulmonary arte-theory, pericardial effusion, and  hypertrichosis. papyrus when a single application radrenoblokatorov mean  arterial pressure drops usually insignificantly (with isolated systolic  hypertension, blood pressure may drop and after a papyrus of the application  papyrus ? blockers). Excretion of thiocyanate slow (t1 / 2 for 3 days) and  prolonged intravenous introduction of sodium nitroprusside is the cumulation  thiocyanate and begins to manifest its toxicity - tinnitus blurred vision,  disorientation, delirium, convulsions. Simultaneously, ? blockers narrow the  blood vessels (block ?2 adrenoceptor). Nitroglycerine dilates predominantly Percutaneous  Myocardial Revascularisation and papyrus a lesser extent arterial vessels here  that the level of thiol enzymes, which are under the influence of nitroglycerin  released N0, in veins than in arteries). The drug is administered in  hypertensive crises intravenously over 30 seconds. Decreases ingibiruyushee  fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. The drug used  for relief hypertensive crises, as well as to reduce Intima-media Thickness  load on the heart in acute heart failure. 
 
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